The Supplements Geek
Health, Wellness, and More...

NMN supplements featured image

NMN Supplement: The Ultimate Guide to Renewed Health

Are you curious about how NMN supplements could potentially transform your health and wellness journey? Look no further! In this comprehensive guide, we’ll explore the science behind nicotinamide mononucleotide (NMN) supplements and uncover their numerous benefits, from anti-aging to enhanced cognitive function. We’ll also touch on clinical studies, safety precautions, and discuss whether NMN is the right supplement for you.

What is an NMN Supplement?

An NMN supplement is any form of supplement or dietary aid that contains nicotinamide mononucleotide, or simply NMN. NMN is a naturally occurring molecule found in all living organisms.

NMN supplements usually come in the form of oral capsules, tablets, or powders. They are designed to boost the levels of NAD+ in the body. By increasing NAD+ levels, these supplements aim to improve energy metabolism, promote cellular repair, and potentially slow the aging process. It plays a crucial role in cellular metabolism and energy production by acting as a precursor to nicotinamide adenine dinucleotide (NAD+), an essential coenzyme in the body.

NMN Supplement Science

Nicotinamide Mononucleotide (NMN) is a derivative of vitamin B3 that plays a crucial role in the production of NAD+ (Nicotinamide Adenine Dinucleotide), a coenzyme found in all living cells. NAD+ is essential for energy metabolism and maintaining proper cell function. As we age, the levels of NAD+ in our bodies decline, which can lead to a variety of age-related health issues.

What is NAD+?

We’ve talked a lot about NAD+ so far, and you’re probably wondering what this is, and why it is always connected with NMN.

NAD+ stands for Nicotinamide Adenine Dinucleotide. It’s a coenzyme found in all living cells and is critical for several key biological processes. It plays a crucial role in energy metabolism by helping convert the food we eat into the energy our cells need to perform their functions. It does this by accepting and donating electrons during metabolic reactions, particularly those involved in the production of ATP (adenosine triphosphate), the main energy currency of the cell.

As we age, the levels of NAD+ in our bodies decline, which can lead to a variety of age-related health issues. This has led to interest in strategies to boost NAD+ levels, such as supplementation with NAD+ precursors like NMN and NR (Nicotinamide Riboside).

To truly comprehend the significance of NAD+, consider its role in mitochondrial function – the powerhouse of every cell. A healthy mitochondria ensures sufficient energy production to fuel all bodily functions efficiently.

By supporting key enzymes like SIRT3 Activation Complex with NMN supplementation, you’re not only boosting healthy levels of NAD+, but also promoting optimal mitochondrial performance which ultimately improves metabolism and delays aging-associated declines.

How NMN Increases NAD+ Levels

NMN supplements are well-known for their ability to boost NAD+ levels in the body, a molecule vital for overall health and wellness. To better understand how this process works, it’s essential to first delve into the relationship between NMN and NAD+.

This conversion process relies on an enzyme called NAMPT (Nicotinamide Phosphoribosyltransferase). As we age, both our levels of NAMPT and naturally-produced NMN decline, resulting in a decrease in cellular energy production.

By supplementing with additional NMN through high-quality nutritional supplements, you can effectively circumvent this limitation, ramp up your body’s own natural metabolism of nutrients, and increase your overall energy production.

What Are The Health Benefits of NMN Supplements?

NMN supplements offer numerous health benefits, including anti-aging effects, improved cognitive function, increased energy and endurance, enhanced metabolism, improved cardiovascular health, reduced inflammation, and potential cancer prevention.

Does NMN Have Anti-aging Effects?

One of the most sought-after benefits is NMN anti-aging effects. As we age, our NAD+ levels naturally decline, leading to numerous health issues like weight gain and glucose intolerance.

Studies have also shown that NMN can improve brain health, enhance cardiovascular function, and reduce inflammation in the body – all factors closely linked to aging.

Can NMN Help Improve Skin Health?

Research suggests that NMN can lead to improved skin quality, health, and revitalize the appearance of your skin. Skin is an important part of us. It’s the largest organ in our body, and helps create a first impression that lasts. The first thing people see is our facial skin. Using NMN supplements made for your skin can really help do wonders.

NMN and Health Conditions

Research has indicated that NMN may be beneficial in managing health conditions associated with aging like heart disease, Alzheimer’s, and diabetes. However, while preliminary results are promising, further research is needed to fully understand NMN’s potential impact on these health conditions.

Does NMN Improve Cognitive Function?

NMN supplements have been shown to improve cognitive function by promoting neurogenesis, the development of new neurons in the brain. Studies have demonstrated that increased NAD+ levels, which NMN supplementation can achieve, play a critical role in brain health and can lead to improved memory, learning ability, and overall mental function.

Additionally, models of Alzheimer’s disease have shown promising results with NMN treatment, suggesting that this supplement may be effective in preventing or slowing cognitive decline associated with aging or neurodegenerative diseases.

Does NMN Increase Energy and Endurance?

One of the most notable benefits of NMN supplements is increased energy levels and endurance. As a precursor to NAD++, a coenzyme found in every living cell that plays a crucial role in energy metabolism, increasing levels of NMN can stimulate the metabolic system and enhance the body’s ability to convert food into energy.


This can be particularly helpful for those looking to improve their athletic performance or combat fatigue. Additionally, research suggests that supplementation with NMN may help lower obesity by promoting healthy metabolism, making it an excellent supplement for those seeking better overall health outcomes.

Overall, incorporating NMN supplements into your routine could lead to improved physical performance, higher energy levels throughout the day, and a healthier metabolic system.

How Does NMN Enhance Metabolism?

NMN supplements have been found to enhance metabolism, which is the body’s ability to convert nutrients into energy. This can lead to improved weight management and better nutrient absorption.

When our metabolism functions optimally, it helps regulate many bodily processes such as hormonal balance, cardiovascular health, and cellular metabolism. By supplementing with NMN, you may experience noticeable changes in your energy levels and overall health.

It’s important to note that while NMN supplementation has shown promising results in animal studies regarding metabolic function, more human studies are needed to fully understand its effects on humans’ metabolic health.

Hoes Does NMN Improve Cardiovascular Health?

NMN supplements improve cardiovascular health in several ways. They increase levels of NAD+ in the heart, which protects it from injury and failure.

Chronic supplementation of NMN has also been found to reduce inflammation, which can be a risk factor for heart disease. 

Additionally, studies have shown that regular use of NMN supplements may help with metabolic disorders such as diabetes by improving insulin sensitivity and glucose tolerance.

Does NMN Reduce Inflammation?

One of the key benefits of taking NMN supplements is reduced inflammation in the body. Inflammation can be a root cause of many chronic health conditions, including cardiovascular disease and neurodegenerative disorders like Alzheimer’s.

Studies have shown that NMN supplementation can help reduce age-related adipose tissue inflammation and dry-eye inflammation in mice.

Regular intake of NMN supplements has also been linked to other significant anti-aging benefits, enhanced metabolism, improved energy levels as well as immune function improvements which are critical for staying vibrant into old age.

If you’re concerned about managing chronic conditions or just want to improve your overall health naturally without prescription medications, adding an NMN supplement to your daily routine could be a smart choice.

Clinical Studies On NMN Supplements

Researchers have conducted multiple clinical studies on NMN supplements, revealing promising findings such as improvements in energy metabolism, DNA repair, and cellular health.

Clinical studies on NMN supplements have yielded promising results. A human trial found that NMN supplementation increased NAD+ levels, which is associated with aging and may have an influence on aging in humans.

In addition to its anti-aging effects, NMN has been found to improve cognitive function and memory in studies on Alzheimer’s disease.

A multicenter, randomized, double-blind clinical trial found that NMN supplementation improved arterial stiffness and endothelial function. Endothelial dysfunction is a key factor in the development of cardiovascular diseases such as hypertension, coronary artery disease, and stroke.

This study suggests that supplementing with NMN could potentially reduce the risk of these conditions by improving cardiovascular health.

How To Choose The Right Form and Brand of NMN Supplement

Choosing the right form and brand of NMN supplement can be overwhelming, but it’s important to consider factors such as bioavailability, purity testing, delivery method, and optimal dosing.

Look for supplements that have undergone third-party testing to ensure purity and potency. Some forms may be more bioavailable than others; for example, sublingual or chewable tablets may be absorbed more quickly than capsules.

nmn supplement pills

It is also recommended to start with a lower dose and gradually increase over time while monitoring any potential side effects. Some reputable brands include Neurogan, ProHealth Longevity, and Elevant NMN+.

Who Should Take NMN Supplements?

NMN supplements may be beneficial for individuals experiencing age-related decline in NAD+, chronic conditions, or athletes and fitness enthusiasts looking to enhance their performance.

Age-related Decline In NAD+

As we age, our bodies undergo a natural process of decline that can lead to various health issues, such as decreased metabolism and cognitive function. One significant factor attributed to this process is the depletion of NAD+ levels in the body over time.

NAD+ plays a crucial role in numerous cellular processes, including energy production and DNA repair.

Fortunately, NMN supplements have been shown to increase NAD+ levels in animal studies and potentially mitigate some symptoms associated with aging-related complications.

Chronic Health Conditions

For individuals with chronic conditions such as diabetes or heart disease, NMN supplements may help certain health conditions. Studies have shown that increased levels of NAD+ can improve cardiovascular health and reduce inflammation, which are both critical factors in managing these conditions.

In addition, NMN supplementation has been found to enhance the body’s ability to turn food into energy, which can be an effective tool in lowering obesity – a common risk factor for many chronic diseases.

Athletes and Fitness Enthusiasts

For athletes and fitness enthusiasts, NMN supplements can offer a range of benefits. NMN increasing endurance performance is one such benefit that has been observed in middle-aged athletes by improving aerobic capacity.

In addition to this, NMN supplementation may also reduce the risk of heart disease and improve metabolic disorders such as insulin sensitivity. The supplement may also have positive effects on muscle endurance and aging biomarkers.

Miss Fitness Universe is known to be an enthusiast for NMN supplements, taking them regularly to experience their benefits. Early studies suggest that taking up to 1,200 mg per day may provide health benefits related to athletic performance and overall fitness level improvements.

Is NMN Legal in the United States?

Yes, NMN is legal, but recent legislation changes removed it from a dietary supplement list. In late 2022, the FDA declared that NMN cannot be used as a dietary ingredient due to its previous examination as a pharmaceutical substance. This decision was made following the agency’s awareness of recent drug research involving this ingredient.

Just because something can’t be considered as a dietary supplement doesn’t make it illegal. It just means if you purchase it, it cannot be labeled as a dietary supplement. Ever head of the popular supplement CBD? CBD is in a similar position as NMN.

NMN Dosage Recommendations

When it comes to taking NMN supplements, the recommended dosage can vary depending on factors such as age, health status, and weight. While there is no official dosage guideline for NMN supplements yet, most brands offer between 250mg – 750mg per serving.

It’s important to note that long-term oral doses of up to 300 mg/kg of NMN have been found to be safe and well-tolerated in normal mice. For human supplements, daily doses usually range around a few hundred milligrams per day. However, researchers are still conducting more studies on the efficient dosage for humans.

It is always best to start with a lower dosage and gradually increase over time as needed.

Consult with a healthcare professional before starting any new supplement regimen, as certain medications or health conditions may interact with NMN supplements.

What Time of Day Should I Take NMN?

When it comes to incorporating NMN supplements into your routine, timing and frequency of use are important considerations. It’s recommended to take NMN in the morning or early afternoon since it can increase energy levels that could disrupt sleep if taken too late in the day.

As for dosage, it’s best to start low and gradually increase over time.

Consistency is key when taking NMN supplements as well. Since its effects build up over time, it’s essential to take them regularly and not miss doses. It’s also worth noting that everyone responds differently to supplements, so patience may be necessary to see results.

Difference Between NMN vs. NAD+ Supplements

What’s the differences between NMN and NAD+?

This is, probably, the most common question we get when it comes to this supplement.

NMN and NAD+ are two popular anti-aging supplement ingredients that are often confused with each other. Although they perform similar roles in the body, there are distinct differences between them.

NMN is a precursor to NAD++, which means that it converts into NAD+ once inside the body. On the other hand, NAD+ is a coenzyme found in every cell of our bodies, responsible for many cellular processes including energy metabolism.

While both supplements can increase NAD+ levels and provide multiple health benefits such as improved cognitive function and enhanced metabolism, NMN may be more effective at increasing those levels due to its bioavailability compared to NAD+.

Is NMN or NAD+ Better?

If you’re deciding between NMN and NAD+ supplements, it’s essential to understand the difference. NMN is a precursor to NAD++, while NAD+ directly replenishes your body’s levels of this critical coenzyme.

Both have demonstrated impressive benefits for anti-aging and improved physiological functions, but they work differently in the body. NMN has shown promising results in clinical studies for its ability to increase energy levels, reduce inflammation, and improve cardiovascular health as well as decrease aging-associated pathologies.

On the other hand, NAD + protected against neuronal dysfunction and oxidative stress that may lead to cognitive decline with age.

Safety Profile and Side Effects of NMN Supplement

When it comes to taking NMN supplements, safety is always a top concern. The good news is that there have been no reports of significant adverse effects associated with NMN supplementation in humans.

However, some NAD+ boosting supplements, when taken at high levels, may cause side effects such as nausea, diarrhea, flushing, and stomach discomfort. It’s essential to stick to the recommended dosage and consult your doctor before starting any new supplement regimen.

Short-term use of NMN supplements is generally safe for healthy individuals with no reported severe side effects. In numerous studies, supplementation with NMN has increased NAD+ biosynthesis while suppressing age-related adipose tissue inflammation and enhancing insulin secretion.

NMN Interactions With Medications

Research has found that taking NMN supplements alongside other supplements or medications may enhance its benefits even further. For example, some studies suggest that combining NMN with resveratrol – a compound found in red wine – can help improve cognitive function and increase longevity.

This is because both compounds work to activate sirtuins, which are proteins that help regulate aging and metabolism.

Furthermore, incorporating NMN supplements into your routine can be part of a larger strategy to support overall health and wellness through vitamins and minerals. While NMN isn’t advertised for weight loss purposes specifically, increasing NAD+ levels with NMN may help manage obesity over time by improving metabolism and reducing inflammation.

Long-term Safety

When it comes to taking supplements, one of the main concerns is their long-term safety. As for NMN supplements, preclinical studies have shown that boosting NAD+ abundance with precursor compounds like NMN has profound health benefits, but we still need more research on its long-term safety.

The article notes that while clinical studies on NMN supplements have not reported any serious adverse effects so far, we cannot conclusively say whether there are any risks associated with prolonged use.

Natural Food Sources of NMN

While NMN can be naturally found in certain foods such as avocado, broccoli, and cabbage, it is not present in high enough levels to provide the same benefits that NMN supplements offer.

For instance, you would need to eat over 100 cups of broccoli a day to get the equivalent amount of NMN found in one capsule! Obviously, taking an NMN supplement is the most effective way to increase the body’s NAD+ levels.

Incorporating a healthy diet alongside an NMN supplement may also provide additional benefits for overall health and metabolic function.

Summary – Determining If NMN Supplements Are Right For You

If you’re considering adding NMN supplements to your daily routine, it’s important to assess whether they’re right for you. NMN has potential health benefits that may particularly appeal to older adults, athletes and fitness enthusiasts, and individuals with chronic conditions.

The anti-aging effects of NMN can help boost energy levels, improve cognitive function, and enhance metabolism.

It’s also essential to consider factors such as dosage recommendations, purity of the supplement brand selected among other things when choosing an NMN supplement.

While more studies are needed to fully understand the effects of taking these supplements long-term use or determining its suitability will highly depend on individual needs and health goals.

Common Questions About NMN Supplements

What is NMN supplement good for?

NMN (Nicotinamide Mononucleotide) is a supplement that’s often touted for its potential anti-aging benefits. It’s a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a compound that plays a crucial role in energy metabolism and maintaining cellular health. The levels of NAD+ in the body decline with age, and this has been linked to a variety of age-related health issues.

What are the disadvantages of NMN supplements?

Potential Side Effects: Some users of NMN supplements have reported side effects such as mild nausea, fatigue, headaches, diarrhea, stomach discomfort, and indigestion, although these appear to be relatively rare.

Cost: NMN supplements can be quite expensive, which may be a consideration for some people.

Are NMN supplements legit?

Yes, NMN supplements are legitimate in the sense that they contain Nicotinamide Mononucleotide, a compound which can increase levels of NAD+ in the body. 

Is NMN hard on kidneys?

There isn’t conclusive evidence to suggest that NMN (Nicotinamide Mononucleotide) is harmful to the kidneys. NMN is a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a compound that plays a crucial role in energy metabolism and maintaining cellular health. Some studies suggest that NMN might have potential benefits in preventing age-related decline in organ function, including the kidneys.


In conclusion, understanding the benefits and science behind NMN supplements can provide numerous advantages for individuals in terms of anti-aging effects, cognitive function improvements, increased energy levels, enhanced metabolism support, improved cardiovascular health, reduced inflammation rates and potentially lower cancer risks.

Research shows that taking NMN supplements can help boost NAD+ levels in our bodies while providing the energy we need to stay healthy. The comprehensive guide provided here will give you all the information you need to make informed decisions about using NMN supplements safely and effectively.

Peered Reviewed References and Source

  1. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR by Jun Yoshino, Joseph A. Baur, Shin-ichiro Imai, published in 2018. This paper discusses the biology of NAD+ and the potential therapeutic effects of its intermediates, NMN and NR.
  2. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice by Kathryn L. Mills, Shohei Yoshida, Liana R. Stein, Alessia Grozio, Shunsuke Kubota, Yo Sasaki, Philip Redpath, Marie E. Migaud, Rajendra S. Apte, Koji Uchida, Jun Yoshino, Shin-ichiro Imai, published in 2016. This study discusses the effects of long-term NMN administration on age-associated physiological decline in mice.
  3. Nampt/PBEF/Visfatin Regulates Insulin Secretion in β Cells as a Systemic NAD Biosynthetic Enzyme by Javier R. Revollo, Antje Körner, Kathryn L. Mills, Takunori Satoh, Tao Wang, Antje Garten, Biplab Dasgupta, Yo Sasaki, Cynthia Wolberger, Raymond R. Townsend, Jeffrey Milbrandt, Wieland Kiess, Shin-ichiro Imai, published in 2007. This paper discusses the role of NMN in regulating insulin secretion in β cells.

Meet the Author Behind the Articles

supplements geek favicon-150_115

George’s journey into the world of supplements began as a personal quest to improve his own athletic performance. Leveraging his background in mechanical engineering and analytical thinking, he meticulously tests and measures the effects of various supplements on his sports output, using the scientific method to ensure accuracy and reliability in his findings. Read more about George Grey.

Check out more articles by The Supplements Geek

Share on social:
Table of Contents
Scroll to Top